Coupling reactions serve to link parts of an organic molecule by forming carbon-carbon bonds (C-C) or carbon nitrogen (C-N) bonds. Such reactions are used for pharmaceuticals, agro- and fine chemicals.

These coupling reactions are based on Pd(0) and Pd(II) precursors with added special ligands. Various coupling reactions (named after their inventors "Suzuki", "Matsuda", "Stille", etc.) are based on this palladium chemistry and play a crucial role in the efficient production of important products like biphenyls for pharma- and agrochemicals.

Heraeus has a broad portfolio of palladium phosphine catalysts as shown in our brochure. Depending on the coupling reaction of choice, one palladium phosphine catalyst may be preferred over the other. Moreover, Heraeus has developed a new phosphine ligand called SabPhos. As shown in our new brochure it is proven to build up C-N bonds in much milder conditions as other commonly used catalysts such as Xphos.